The Madfolio package works great in all major browsers (Internet Explorer 9+, Safari, Firefox, Chrome and Opera). Older versions of the IE are not supported.
The Add-On works with all standard Concrete5 blocks. 3rd-party blocks are untested and may work, but there is no guarantee that they will.
Since the idea of an automatically generated grid layout compromises the build-in C5 layout function, it is not recommended to combine both features in one page!
The add-on requires at least concrete5 version 5.6.0 to be installed and PHP version 5.3+ to run on your web server.